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Paper   IPM / Biological Sciences / 17297
School of Biological Sciences
  Title:   Excitatory deep brain stimulation quenches beta oscillations arising in a computational model of the subthalamo-pallidal loop
  Author(s): 
1.  Seyed Mojtaba Alavi
2.  Amin Mirzaei
3.  Alireza Valizadeh
4.  Reza Ebrahimpour
  Status:   Published
  Journal: Scientific Reports
  Year:  2022
  Supported by:  IPM
  Abstract:
Parkinson’s disease (PD) is associated with abnormal beta band oscillations (13–30 Hz) in the corticobasal ganglia circuits. Abnormally increased striato-pallidal inhibition and strengthening the synaptic coupling between subthalamic nucleus (STN) and globus pallidus externa (GPe), due to the loss of dopamine, are considered as the potential sources of beta oscillations in the basal ganglia. Deep brain stimulation (DBS) of the basal ganglia subregions is known as a way to reduce the pathological beta oscillations and motor defcits related to PD. Despite the success of the DBS, its underlying mechanism is poorly understood and, there is controversy about the inhibitory or excitatory role of the DBS in the literature. Here, we utilized a computational network model of basal ganglia which consists of STN, GPe, globus pallidus interna, and thalamic neuronal population. This model can reproduce healthy and pathological beta oscillations similar to what has been observed in experimental studies. Using this model, we investigated the effect of DBS to understand whether its effect is excitatory or inhibitory. Our results show that the excitatory DBS is able to quench the pathological synchrony and beta oscillations, while, applying inhibitory DBS failed to quench the PD signs. In light of simulation results, we conclude that the effect of the DBS on its target is excitatory.

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